|
ASTHMA, SUSCEPTIBILITY TO (finding)
|
0.100 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
ALLERGIC RHINITIS, SUSCEPTIBILITY TO
|
0.100 |
SusceptibilityMutation
|
phenotype |
CLINVAR |
|
|
|
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma.
|
16461126 |
2006 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Surface expression of very late antigen-4 [VLA-4] and LFA-1 was decreased and the production of the type 2 cytokines IL-5 and IL-13 was augmented by the presence of IL-4 during stimulation of CD8+ T cells from mild atopic asthmatics.
|
16001979 |
2005 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
This augmentation of TGF-beta1-induced TIMP-1 by IL-13 could contribute to the fibrosis and airway remodeling seen in the presence of T(H)2 inflammation in asthma.
|
17418380 |
2007 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Persistence of experimental asthma in ST2 KO mice was associated with an increase in levels of thymic stromal lymphopoietin (TSLP), IL-9, and IL-13, but not IL-5, in bronchoalveolar lavage fluid.
|
29132961 |
2018 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Those with asthma had higher serum interferon (IFN)-α, but lower serum tumour necrosis factor, interleukin (IL)-5, IL-6, CXCL8, CXCL9, IL-10, IL-17 and CCL2 levels (all p<0.05); both groups had similar serum IL-13, total IgE, periostin and blood eosinophil gene expression levels.
|
31391224 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the epithelium, IL-13 response genes (POSTN, SERPINB2, and CLCA1), mast cell mediators (CPA3 and TPSAB1), inducible nitric oxide synthase, and cystatins (CST1, CST2, and CST4) were upregulated in mild asthma, but, except for cystatins, were suppressed by corticosteroids in moderate asthma.
|
28933920 |
2018 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Th2 asthma is mediated by allergen-specific Th2 cells, and eosinophils activated by Th2 cells via the secretion of interleukin (IL)-4, IL-5, and IL-13.
|
31776937 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We then defined type 2 status in 25 healthy subjects, 28 patients with mild asthma, 29 patients with moderate asthma, and 26 patients with severe asthma based on airway mucosal expression of (1) CCL26 (the most differentially expressed gene), (2) periostin, or (3) a multigene IL-13 in vitro signature (IVS).
|
28089872 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our analysis revealed that without any overt stimulation, mRNA transcripts for interleukin (IL)-5 and IL-13 were expressed by asthmatic but not normal bronchial tissue.
|
9870929 |
1999 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
EBC and serum ezrin levels correlated with lung function in patients with asthma and serum ezrin levels were negatively correlated with serum IL-13 and periostin.
|
30290132 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Additionally, in the OVA-induced asthma model, the number of immune cells in the bronchoalveolar lavage fluid, the concentration of OVA-specific IgE, the infiltration of inflammatory cells, the bronchial thickness and the levels of the inflammatory mediators interleukin-4 (IL-4), IL-13 and COX-2 were significantly lower in the OVA + SEAC‑treated group compared with the OVA + vehicle‑treated group.
|
28949387 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The mean IL-13 serum cytokine levels were found to be significantly high in atopic (38.48 ± 36.54) and non-atopic (36.05 ± 34.54) asthma patients whereas total serum IgE levels were significantly high at p < 0.0001 in atopic and low in non-atopic asthma patients at p < 0.003 compared to HC.
|
28083766 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that hsa_circ_0005519 may induce IL-13 and IL-6 expression by regulating hsa-let-7a-5p in CD4<sup>+</sup> T cells to affect asthma.
|
31148290 |
2019 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Neutrophilic bronchiectasis exhibited comparable IL-8 levels to COPD, whereas eosinophilic bronchiectasis showed significantly lower IL-13 levels compared to asthma.
|
28863927 |
2017 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To identify how effects of IL-13 on airway epithelial cells contribute to gene expression changes in murine asthma models and determine whether similar changes are seen in people with asthma.
|
16083784 |
2005 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Using microarray and polymerase chain reaction analyses of airway epithelial brushings from 42 patients with mild-to-moderate asthma and 28 healthy control subjects, we classified subjects with asthma based on high or low expression of IL-13-inducible genes.
|
19483109 |
2009 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Additionally, IL-13, IL-10 and eosinophil major basic protein mRNA levels were greater in patients with asthma exacerbations compared to non-exacerbating patients (P = 0.03, P = 0.06 and P = 0.02, respectively), and IL-13 mRNA correlated with the peak Asthma Index (P = 0.006).
|
24450586 |
2014 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We propose that: (i) IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and (ii) by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma.
|
15677460 |
2005 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
|
12813015 |
2003 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We evaluated IL-1 alpha, -2, -4, -5, -6, -13, and granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon-gamma (IFN-gamma). mRNAs for IL-1 alpha, -2, -4, -5, and IFN-gamma were detected in all of the atopic subjects; mRNAs for IL-6 and GM-CSF were found in five asthmatics; and mRNA for IL-13 was found in one patient only.
|
9087947 |
1997 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Because exaggerated cytokine production is a characteristic feature of the asthmatic airway, we used constitutive and inducible overexpression transgenic systems to investigate the contributions that interleukin 11 (IL-11) and IL-13 might make to airway remodeling responses.
|
11734470 |
2001 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
STAT6 links IL-4/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease.
|
21814192 |
2011 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Sputum IL-4, IL-5 and IL-13 protein levels did not correlate with gene expression.T2-high severe asthma can be predicted to some extent from raised levels of <i>F</i><sub>eNO</sub>, blood and sputum eosinophil counts, but serum IgE or serum periostin were poor predictors.
|
30578390 |
2019 |